Phospholipid dephosphorylation

Across TCGA cell cohorts, RNA activity of the Phospholipid dephosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIK3CA, EDC4, and ZNF639, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phospholipid dephosphorylation activity versus PIK3CA in LUNG_NSCLC_LUSC (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PIK3CA →	+1.340	+1.417	.004	<.001	3	6
BREAST	EDC4 →	+0.732	+0.756	<.001	.004	3	6
OESOPHAGUS	ZNF639 →	+1.352	+1.620	.001	<.001	3	5
LUNG_NSCLC_LUSC	DCUN1D1 →	+1.071	+1.063	.009	.004	3	5
PANCREAS	ODF2 →	+0.983	+0.933	.009	.004	3	4
PANCREAS	RANBP10 →	+0.581	+0.828	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046839 vs PIK3CA — LUNG_NSCLC_LUSC

Explore this scatter interactively →