Glycolipid transport

Across TCGA patient cohorts, RNA activity of the Glycolipid transport pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are XPO1, DNAJC2, and AVL9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycolipid transport activity versus XPO1 in LUAD (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	XPO1 →	+0.093	+0.032	.001	<.001	3	6
BRCA	DNAJC2 →	+0.347	+0.032	.002	.002	3	6
LUAD	AVL9 →	+0.344	+0.044	.001	.002	3	5
BRCA	BLNK →	-0.317	-0.031	.001	.003	3	5
LUAD	GLS →	+0.458	+0.036	.008	.006	3	5
COAD	ATP2B1_S1178 →	-0.552	-0.025	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046836 vs XPO1 — LUAD

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