Glycolipid transport

Across TCGA patient cohorts, RNA activity of the Glycolipid transport pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FGF12, SLC41A1, and FREM2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycolipid transport activity versus FGF12 in HNSC (Pearson r = -0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FGF12 →	-0.962	-0.118	<.001	<.001	3	4
CCRCC	SLC41A1 →	-0.401	-0.102	<.001	.004	3	4
LSCC	FREM2 →	-1.672	-0.100	<.001	<.001	3	4
CCRCC	RAPGEF4 →	-0.594	-0.100	.004	.001	3	4
LSCC	BLMH →	-0.619	-0.107	.003	.004	3	4
HNSC	KBTBD7 →	-0.505	-0.085	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046836 vs FGF12 — HNSC

Explore this scatter interactively →