Glycolipid transport

Across TCGA cell cohorts, RNA activity of the Glycolipid transport pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMM8B, PIM2, and ATG14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TIMM8B grouped by Glycolipid transport-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TIMM8B →	-0.630	-1.223	<.001	.001	3	4
BLOOD_Leukemia	PIM2 →	-1.961	-1.510	.009	.001	3	4
KIDNEY	ATG14 →	+0.960	+1.358	.001	.001	3	4
KIDNEY	NUMB →	+1.004	+1.543	.004	<.001	3	4
LUNG_SCLC	FAU →	-0.452	-1.054	.007	.009	3	4
BONE	TOR1AIP2 →	+0.561	+1.154	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TIMM8B by Glycolipid transport activity — LARGE_INTESTINE

Explore this box plot interactively →