Glycolipid transport

Across TCGA cell cohorts, RNA activity of the Glycolipid transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPC2, CHCHD4, and SPINT1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycolipid transport activity versus NPC2 in LUNG_NSCLC_LUAD (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NPC2 →	+2.018	+1.458	<.001	<.001	3	7
PANCREAS	CHCHD4 →	-1.099	-1.377	<.001	.001	3	5
LUNG_NSCLC_LUAD	SPINT1 →	+4.025	+1.347	<.001	<.001	3	5
STOMACH	REEP3 →	+1.136	+0.891	.004	.005	3	4
LARGE_INTESTINE	DTWD1 →	-0.799	-0.943	.004	.003	2	5
PANCREAS	CD63 →	+0.770	+1.038	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046836 vs NPC2 — LUNG_NSCLC_LUAD

Explore this scatter interactively →