Lipid phosphorylation

Across TCGA patient cohorts, RNA activity of the Lipid phosphorylation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TAGLN_S7, FBLIM1, and ITGA5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid phosphorylation activity versus TAGLN_S7 in COAD (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TAGLN_S7 →	-0.522	-0.040	.007	.002	3	5
GBM	FBLIM1 →	-0.467	-0.054	.005	.003	3	5
COAD	ITGA5 →	-0.433	-0.042	.006	.005	3	5
LSCC	BNC2_S403 →	-0.450	-0.040	.004	.009	3	5
GBM	MICAL2_S515 →	-1.019	-0.085	<.001	<.001	3	5
HNSC	AKAP1 →	+0.311	+0.068	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046834 vs TAGLN_S7 — COAD

Explore this scatter interactively →