Positive regulation of RNA export from nucleus

Across TCGA patient cohorts, RNA activity of the Positive regulation of RNA export from nucleus pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GMPS, SDF2, and RAB6B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of RNA export from nucleus activity versus GMPS in LSCC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GMPS →	+0.487	+0.049	<.001	<.001	3	7
LSCC	SDF2 →	+0.355	+0.039	<.001	<.001	3	7
LSCC	RAB6B →	+1.335	+0.052	<.001	<.001	3	7
HNSC	SERPINB1 →	-0.505	-0.075	<.001	<.001	3	6
UCEC	TMOD3 →	-0.230	-0.058	.003	.002	3	6
HNSC	IGF2BP2 →	+0.717	+0.087	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046833 vs GMPS — LSCC

Explore this scatter interactively →