Positive regulation of RNA export from nucleus

Across TCGA cell cohorts, RNA activity of the Positive regulation of RNA export from nucleus pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PA2G4, PCBP2, and HNRNPL, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of RNA export from nucleus activity versus PA2G4 in SKIN (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PA2G4 →	+0.414	+0.079	.008	.001	3	5
UPPER_AERODIGESTIVE_TRACT	PCBP2 →	+1.002	+0.265	.006	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	HNRNPL →	+0.812	+0.155	<.001	.001	2	6
UPPER_AERODIGESTIVE_TRACT	NUP210 →	+3.108	+0.171	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	EML4 →	+1.060	+0.160	<.001	.001	3	5
BLOOD_Leukemia	TCF3 →	+1.172	+0.046	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046833 vs PA2G4 — SKIN

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