Positive regulation of RNA export from nucleus

Across TCGA cell cohorts, RNA activity of the Positive regulation of RNA export from nucleus pathway is significantly associated with the protein abundance of multiple proteins, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CPSF6, ZNF207, and EWSR1, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of RNA export from nucleus activity versus CPSF6 in OESOPHAGUS (Pearson r = 0.83).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CPSF6 →	+1.022	+0.148	.004	.003	3	19
UPPER_AERODIGESTIVE_TRACT	ZNF207 →	+1.676	+0.226	<.001	<.001	3	16
OESOPHAGUS	EWSR1 →	+1.573	+0.156	.001	.001	3	15
UPPER_AERODIGESTIVE_TRACT	CCAR1 →	+0.971	+0.220	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	TAF15 →	+1.430	+0.201	.002	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	SRSF11 →	+1.089	+0.143	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046833 vs CPSF6 — OESOPHAGUS

Explore this scatter interactively →