Regulation of RNA export from nucleus

Across TCGA patient cohorts, RNA activity of the Regulation of RNA export from nucleus pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPP1R10_S313, SF3B5, and MAD1L1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of RNA export from nucleus activity versus PPP1R10_S313 in HNSC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PPP1R10_S313 →	+0.426	+0.669	<.001	<.001	3	6
GBM	SF3B5 →	+0.314	+0.877	<.001	.001	3	5
GBM	MAD1L1 →	+0.245	+1.171	<.001	<.001	3	5
BRCA	MCMBP →	+0.322	+0.643	<.001	<.001	2	6
GBM	NUP54 →	+0.263	+1.341	<.001	<.001	3	5
GBM	POLR2E →	+0.242	+0.898	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046831 vs PPP1R10_S313 — HNSC

Explore this scatter interactively →