Positive regulation of protein export from nucleus

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein export from nucleus pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLXDC2, SLC2A5, and PDLIM7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein export from nucleus activity versus PLXDC2 in PDAC (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PLXDC2 →	+0.483	+0.174	.003	.005	3	5
LSCC	SLC2A5 →	+0.410	+0.163	<.001	.003	3	4
LSCC	PDLIM7 →	+0.501	+0.202	.001	.003	3	4
COAD	NAP1L3 →	+0.749	+0.231	<.001	.004	3	4
HNSC	CXCL1 →	-1.029	-0.107	.007	.008	3	4
PDAC	RPS20 →	+0.296	+0.229	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046827 vs PLXDC2 — PDAC

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