Positive regulation of protein export from nucleus

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein export from nucleus pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIAA1191, TTC1, and RARS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KIAA1191 grouped by Positive regulation of protein export from nucleus-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	KIAA1191 →	-1.050	-0.308	<.001	.002	3	6
LUNG_NSCLC_LUSC	TTC1 →	-1.049	-0.361	<.001	.005	3	5
LUNG_NSCLC_LUAD	RARS1 →	-0.523	-0.221	<.001	.001	3	5
BONE	BOD1 →	-0.740	-0.197	.004	<.001	3	5
LUNG_NSCLC_LUAD	RBM22 →	-0.426	-0.235	<.001	<.001	3	5
BONE	HIGD2A →	-0.668	-0.198	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIAA1191 by Positive regulation of protein export from nucleus activity — LIVER

Explore this box plot interactively →