Positive regulation of protein export from nucleus

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein export from nucleus pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLPP1, NBDY, and PLXNB3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein export from nucleus activity versus PLPP1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PLPP1 →	+1.547	+0.180	.001	.003	3	5
BREAST	NBDY →	+1.115	+0.179	.008	<.001	3	5
LUNG_SCLC	PLXNB3 →	+1.212	+0.099	.003	.007	3	5
SKIN	TAZ →	+0.562	+0.145	.001	<.001	3	4
PANCREAS	AVL9 →	+0.784	+0.129	.009	.007	3	4
SKIN	KIAA1549 →	+1.404	+0.143	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046827 vs PLPP1 — UPPER_AERODIGESTIVE_TRACT

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