Negative regulation of protein export from nucleus

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein export from nucleus pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OAS2, IFIT3, and IRF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein export from nucleus activity versus OAS2 in HNSC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	OAS2 →	+1.056	+0.241	.001	<.001	3	6
HNSC	IFIT3 →	+1.967	+0.250	<.001	<.001	3	5
LSCC	IRF1 →	+0.553	+0.141	.002	.002	3	5
HNSC	SP110 →	+1.091	+0.284	<.001	<.001	3	5
LSCC	KIAA1958 →	-0.510	-0.185	<.001	<.001	3	5
GBM	MLKL →	+0.579	+0.368	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046826 vs OAS2 — HNSC

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