Negative regulation of protein export from nucleus

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein export from nucleus pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL34, PIGT, and PRR15, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein export from nucleus activity versus RPL34 in LUNG_NSCLC_LUAD (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RPL34 →	+0.728	+0.193	.001	.001	3	5
LUNG_NSCLC_LUAD	PIGT →	-0.735	-0.208	.001	<.001	3	5
BREAST	PRR15 →	-2.014	-0.178	.005	.001	3	5
URINARY_TRACT	CTAGE4 →	-2.617	-0.265	<.001	.002	3	5
BREAST	MED15 →	-0.727	-0.161	.006	.002	3	5
OVARY	EPS8L1 →	-3.551	-0.256	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046826 vs RPL34 — LUNG_NSCLC_LUAD

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