Regulation of protein export from nucleus

Across TCGA patient cohorts, RNA activity of the Regulation of protein export from nucleus pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYOF, COL8A1, and SYNC, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein export from nucleus activity versus MYOF in CCRCC (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MYOF →	+0.375	+0.145	<.001	.003	3	6
LSCC	COL8A1 →	+0.517	+0.191	.005	<.001	3	5
COAD	SYNC →	+0.750	+0.211	<.001	.006	2	6
OV	CD109 →	+1.007	+0.119	.002	.006	3	5
OV	FAS →	+0.679	+0.157	<.001	.001	3	5
LUAD	AXL →	+0.823	+0.146	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046825 vs MYOF — CCRCC

Explore this scatter interactively →