Regulation of protein export from nucleus

Across TCGA cell cohorts, RNA activity of the Regulation of protein export from nucleus pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC16A8, ACRV1, and BICDL1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC16A8 grouped by Regulation of protein export from nucleus-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SLC16A8 →	+0.856	+0.207	.008	.008	2	7
PANCREAS	ACRV1 →	+0.233	+0.247	.007	.003	3	5
LUNG_SCLC	BICDL1 →	+2.262	+0.232	<.001	.001	3	5
LUNG_SCLC	CDC42BPG →	+2.146	+0.296	.004	.002	3	5
LUNG_SCLC	SBK1 →	+2.178	+0.219	.001	.003	3	5
LIVER	PLOD2 →	-2.539	-0.351	.003	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC16A8 by Regulation of protein export from nucleus activity — STOMACH

Explore this box plot interactively →