Regulation of protein export from nucleus

Across TCGA cell cohorts, RNA activity of the Regulation of protein export from nucleus pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABHD8, ST13, and UHRF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ABHD8 grouped by Regulation of protein export from nucleus-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ABHD8 →	+0.200	+0.116	.007	.009	3	6
PANCREAS	ST13 →	-0.171	-0.150	.002	<.001	3	5
LUNG_NSCLC_LUSC	UHRF1 →	-0.241	-0.115	.005	.001	3	4
LUNG_SCLC	SERHL2 →	+0.176	+0.099	.008	.004	3	4
LIVER	DYRK1A →	-0.314	-0.153	.007	.006	3	4
BLOOD_Leukemia	LRRC28 →	-0.185	-0.101	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ABHD8 by Regulation of protein export from nucleus activity — SOFT_TISSUE

Explore this box plot interactively →