Regulation of protein export from nucleus

Across TCGA cell cohorts, RNA activity of the Regulation of protein export from nucleus pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPM3, UCK2, and LAS1L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein export from nucleus activity versus NPM3 in OVARY (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NPM3 →	+1.140	+0.177	.001	.002	3	5
OVARY	UCK2 →	+0.885	+0.178	.007	.006	3	5
LUNG_NSCLC_LUAD	LAS1L →	+0.696	+0.153	<.001	<.001	3	5
LUNG_NSCLC_LUAD	NEIL2 →	+0.851	+0.188	.005	<.001	3	5
LARGE_INTESTINE	FANCL →	+0.667	+0.164	.001	.003	3	4
LARGE_INTESTINE	PITPNB →	+0.446	+0.105	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046825 vs NPM3 — OVARY

Explore this scatter interactively →