Positive regulation of nucleocytoplasmic transport

Across TCGA patient cohorts, RNA activity of the Positive regulation of nucleocytoplasmic transport pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA11, ACTA2, and TAGLN, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of nucleocytoplasmic transport activity versus ITGA11 in LSCC (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ITGA11 →	+1.055	+0.281	<.001	<.001	3	6
OV	ACTA2 →	+1.186	+0.113	.007	.002	2	7
CCRCC	TAGLN →	+1.121	+0.158	<.001	.001	3	6
LSCC	FBN1 →	+0.741	+0.172	.001	.001	3	6
LSCC	FAP →	+0.906	+0.159	<.001	.008	3	6
CCRCC	TPM2 →	+0.817	+0.168	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046824 vs ITGA11 — LSCC

Explore this scatter interactively →