Positive regulation of nucleocytoplasmic transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of nucleocytoplasmic transport pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM83G, CENPQ, and CD9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM83G grouped by Positive regulation of nucleocytoplasmic transport-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	FAM83G →	+0.818	+0.125	.003	.005	3	5
LARGE_INTESTINE	CENPQ →	-0.527	-0.149	.008	.006	3	5
LUNG_NSCLC_LUSC	CD9 →	-1.498	-0.149	.004	.003	3	4
LUNG_NSCLC_LUSC	GLI4 →	+1.023	+0.192	.007	.005	3	4
LIVER	MAT2B →	-0.816	-0.112	.009	.009	2	5
LIVER	CDC23 →	-0.599	-0.111	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM83G by Positive regulation of nucleocytoplasmic transport activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →