Negative regulation of nucleocytoplasmic transport

Across TCGA cell cohorts, RNA activity of the Negative regulation of nucleocytoplasmic transport pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COQ10A, IQANK1, and PJA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of nucleocytoplasmic transport activity versus COQ10A in LARGE_INTESTINE (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	COQ10A →	+0.756	+0.170	.003	.005	3	6
URINARY_TRACT	IQANK1 →	-5.097	-0.330	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	PJA1 →	+0.844	+0.167	.001	.001	3	5
SOFT_TISSUE	UQCRQ →	+0.502	+0.194	.002	<.001	3	5
LUNG_SCLC	RBMX2 →	+0.538	+0.165	<.001	.005	3	5
LUNG_SCLC	MEX3B →	+0.764	+0.175	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046823 vs COQ10A — LARGE_INTESTINE

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