Regulation of nucleocytoplasmic transport

Across TCGA patient cohorts, RNA activity of the Regulation of nucleocytoplasmic transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDGFRL, RIPOR2, and LRRC31, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of nucleocytoplasmic transport activity versus PDGFRL in BRCA (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PDGFRL →	-2.960	-0.359	.002	.005	3	1
BRCA	RIPOR2 →	-1.076	-0.359	.003	.005	3	1
BRCA	LRRC31 →	-4.253	-0.360	<.001	.005	3	1
BRCA	TTLL7 →	-2.503	-0.359	.004	.005	3	1
BRCA	PRDM5 →	-0.988	-0.295	.004	<.001	3	1
BRCA	MEIS1 →	-2.085	-0.282	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046822 vs PDGFRL — BRCA

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