Regulation of nucleocytoplasmic transport

Across TCGA cell cohorts, RNA activity of the Regulation of nucleocytoplasmic transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHRNG, AMER1, and BCR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHRNG grouped by Regulation of nucleocytoplasmic transport-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CHRNG →	+0.175	+0.317	.003	.003	3	5
BLOOD_Lymphoma	AMER1 →	+0.982	+0.245	.002	.004	3	4
BLOOD_Lymphoma	BCR →	+3.387	+0.319	.001	.003	3	4
STOMACH	TMED9 →	-1.206	-0.197	.002	.005	3	4
CNS	PRDX5 →	-0.679	-0.143	.003	.008	3	4
OVARY	MME →	-2.953	-0.167	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHRNG by Regulation of nucleocytoplasmic transport activity — BLOOD_Lymphoma

Explore this box plot interactively →