Receptor-mediated virion attachment to host cell

Across TCGA patient cohorts, RNA activity of the Receptor-mediated virion attachment to host cell pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VIM_S22, CILP, and PLXDC2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Receptor-mediated virion attachment to host cell activity versus VIM_S22 in PDAC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	VIM_S22 →	+0.569	+0.087	<.001	<.001	3	8
PDAC	CILP →	+0.921	+0.106	<.001	.001	3	8
BRCA	PLXDC2 →	+0.542	+0.087	<.001	<.001	3	8
LSCC	COPZ2 →	+0.840	+0.209	<.001	<.001	3	7
BRCA	SERPINF1 →	+0.828	+0.092	<.001	<.001	3	7
BRCA	SPON1 →	+0.839	+0.082	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046813 vs VIM_S22 — PDAC

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