Receptor-mediated virion attachment to host cell

Across TCGA patient cohorts, RNA activity of the Receptor-mediated virion attachment to host cell pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LOX, BMP4, and CAVIN1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Receptor-mediated virion attachment to host cell activity versus LOX in LSCC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LOX →	+0.655	+0.155	.002	<.001	3	6
BRCA	BMP4 →	+0.959	+0.370	.006	.005	2	7
BRCA	CAVIN1 →	+0.647	+0.420	.002	<.001	3	6
LSCC	GAS6 →	+0.544	+0.107	<.001	<.001	3	6
LSCC	BICC1 →	+0.846	+0.181	<.001	<.001	2	7
BRCA	IFFO1 →	+0.537	+0.361	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046813 vs LOX — LSCC

Explore this scatter interactively →