Receptor-mediated virion attachment to host cell

Across TCGA cell cohorts, RNA activity of the Receptor-mediated virion attachment to host cell pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RGS9, ZBTB34, and CHMP5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RGS9 grouped by Receptor-mediated virion attachment to host cell-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RGS9 →	-1.236	-1.441	.005	.005	3	4
UPPER_AERODIGESTIVE_TRACT	ZBTB34 →	-0.923	-1.833	.004	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	CHMP5 →	-1.459	-1.771	.003	.001	3	3
URINARY_TRACT	ZNF35 →	-0.544	-1.860	.004	.002	3	3
PANCREAS	TMEM263 →	+0.604	+1.330	.009	.004	3	3
LUNG_NSCLC_LUAD	PACSIN2 →	+0.667	+0.692	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RGS9 by Receptor-mediated virion attachment to host cell activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →