Receptor-mediated virion attachment to host cell

Across TCGA cell cohorts, RNA activity of the Receptor-mediated virion attachment to host cell pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAPGEF6, PKN2, and PEMT, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAPGEF6 grouped by Receptor-mediated virion attachment to host cell-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RAPGEF6 →	+0.177	+0.933	.009	.003	3	5
BONE	PKN2 →	+0.210	+1.687	<.001	.002	3	5
SOFT_TISSUE	PEMT →	-0.304	-1.377	<.001	<.001	3	4
SOFT_TISSUE	DIPK1A →	+0.406	+1.927	.003	.004	3	4
SOFT_TISSUE	TSPYL6 →	+0.470	+2.608	.005	<.001	3	4
SOFT_TISSUE	SMPD5 →	-0.326	-1.550	.007	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAPGEF6 by Receptor-mediated virion attachment to host cell activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →