Receptor-mediated virion attachment to host cell

Across TCGA cell cohorts, RNA activity of the Receptor-mediated virion attachment to host cell pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAS6, ICAM1, and CBX2, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Receptor-mediated virion attachment to host cell activity versus GAS6 in BONE (Pearson r = 0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	GAS6 →	+4.308	+1.841	<.001	<.001	3	14
KIDNEY	ICAM1 →	+2.464	+0.313	<.001	<.001	2	15
BONE	CBX2 →	-2.626	-2.034	<.001	<.001	3	9
BONE	ITGA3 →	+4.635	+1.654	<.001	<.001	3	9
BONE	OPTN →	+2.972	+1.799	<.001	<.001	3	9
BLOOD_Lymphoma	EBI3 →	+2.769	+0.639	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046813 vs GAS6 — BONE

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