Receptor-mediated virion attachment to host cell

Across TCGA cell cohorts, RNA activity of the Receptor-mediated virion attachment to host cell pathway is significantly associated with the drug response of multiple features, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are GW441756, KU-60019, and ICL1100013, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GW441756 grouped by Receptor-mediated virion attachment to host cell-low versus -high activity in SKIN.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GW441756 →	-0.585	-0.677	.025	.009	2	1
SKIN	KU-60019 →	-0.580	-0.677	.031	.009	2	1
SKIN	ICL1100013 →	-1.455	-0.677	.011	.009	2	1
SKIN	FEN1_3940 →	-0.434	-0.655	.024	.018	2	1
SKIN	Lapatinib →	-0.755	-0.677	.015	.009	2	1
SKIN	IWP-2 →	-0.424	-0.677	.014	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GW441756 by Receptor-mediated virion attachment to host cell activity — SKIN

Explore this box plot interactively →