Transport of virus

Across TCGA cell cohorts, RNA activity of the Transport of virus pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MECR, NPIPA3, and SSRP1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transport of virus activity versus MECR in LUNG_SCLC (Pearson r = 0.96).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MECR →	+1.061	+0.348	.006	.004	3	2
LUNG_SCLC	NPIPA3 →	+1.315	+0.348	.002	.004	3	2
KIDNEY	SSRP1 →	+0.916	+0.478	.006	<.001	3	2
KIDNEY	FARS2 →	+0.533	+0.320	.004	.003	3	2
KIDNEY	CCDC138 →	+1.199	+0.437	.005	.005	3	2
KIDNEY	ESCO2 →	+1.803	+0.478	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046794 vs MECR — LUNG_SCLC

Explore this scatter interactively →