Regulation of viral transcription

Across TCGA patient cohorts, RNA activity of the Regulation of viral transcription pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COMP, RPL6, and MX2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of viral transcription activity versus COMP in BRCA (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	COMP →	+1.058	+0.039	<.001	<.001	3	6
BRCA	RPL6 →	-0.466	-0.045	<.001	<.001	3	6
GBM	MX2 →	+0.652	+0.047	<.001	<.001	3	5
HNSC	SEPTIN4_S432 →	+0.537	+0.074	<.001	<.001	3	5
CCRCC	SOD3 →	+0.624	+0.030	<.001	.003	3	5
BRCA	SPON1 →	+0.953	+0.037	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046782 vs COMP — BRCA

Explore this scatter interactively →