Regulation of viral transcription

Across TCGA patient cohorts, RNA activity of the Regulation of viral transcription pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RSF1, EMSY, and CEP57, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of viral transcription activity versus RSF1 in LSCC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RSF1 →	+0.370	+0.378	.001	.002	3	5
HNSC	EMSY →	+0.419	+0.486	.002	<.001	3	4
LSCC	CEP57 →	+0.331	+0.314	.001	<.001	3	4
GBM	TROAP →	+0.623	+0.147	.001	.002	3	4
BRCA	SNED1-AS1 →	-0.399	-0.550	<.001	<.001	3	4
UCEC	FBRSL1 →	+0.395	+0.294	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046782 vs RSF1 — LSCC

Explore this scatter interactively →