Regulation of viral transcription

Across TCGA cell cohorts, RNA activity of the Regulation of viral transcription pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDE9A, CDC25A, and ELAVL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PDE9A grouped by Regulation of viral transcription-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PDE9A →	+1.873	+0.954	.001	.002	3	3
SOFT_TISSUE	CDC25A →	+0.819	+0.922	.002	.003	3	3
SOFT_TISSUE	ELAVL1 →	+0.379	+1.004	.004	.001	3	3
KIDNEY	NAT1 →	-0.785	-1.615	.001	<.001	3	3
LUNG_NSCLC_LUSC	ACTA2 →	-1.127	-1.076	.008	.001	3	3
LUNG_NSCLC_LUSC	MARCKSL1 →	+2.497	+1.503	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PDE9A by Regulation of viral transcription activity — SOFT_TISSUE

Explore this box plot interactively →