Regulation of viral transcription

Across TCGA cell cohorts, RNA activity of the Regulation of viral transcription pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAIP1, MARCKSL1, and ZDHHC11, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of viral transcription activity versus MAIP1 in BLOOD_Lymphoma (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MAIP1 →	-0.767	-0.164	.002	<.001	2	6
LUNG_SCLC	MARCKSL1 →	+0.946	+0.188	.003	.006	3	5
BLOOD_Myeloma	ZDHHC11 →	+1.878	+0.188	.002	.002	3	4
LUNG_SCLC	MDM1 →	+1.312	+0.251	<.001	<.001	3	4
OVARY	TUBA1C →	-0.943	-0.385	<.001	<.001	3	4
SOFT_TISSUE	UCHL5 →	-0.871	-0.262	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046782 vs MAIP1 — BLOOD_Lymphoma

Explore this scatter interactively →