Protein autophosphorylation

Across TCGA patient cohorts, RNA activity of the Protein autophosphorylation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TIMP2, RPL5, and TNS2_S102, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein autophosphorylation activity versus TIMP2 in OV (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TIMP2 →	+0.613	+0.059	.003	<.001	3	7
CCRCC	RPL5 →	-0.267	-0.039	<.001	<.001	3	7
OV	TNS2_S102 →	+0.685	+0.035	.005	.002	3	7
GBM	CDH13 →	+0.609	+0.027	<.001	<.001	3	7
CCRCC	CYGB →	+0.627	+0.033	<.001	<.001	3	7
BRCA	YME1L1 →	-0.300	-0.031	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046777 vs TIMP2 — OV

Explore this scatter interactively →