Protein autophosphorylation

Across TCGA cell cohorts, RNA activity of the Protein autophosphorylation pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC35A5, EPHA7, and C4BPB, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC35A5 grouped by Protein autophosphorylation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLC35A5 →	+0.165	+0.146	.005	.006	3	7
OESOPHAGUS	EPHA7 →	-0.153	-0.123	.002	<.001	3	5
OVARY	C4BPB →	-0.154	-0.126	.002	.006	3	4
OESOPHAGUS	ATOH8 →	-0.133	-0.146	.001	.005	2	5
LIVER	GLRA2 →	+0.452	+0.220	.004	.003	3	4
LIVER	RAB5A →	+0.240	+0.178	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC35A5 by Protein autophosphorylation activity — SKIN

Explore this box plot interactively →