Protein autophosphorylation

Across TCGA cell cohorts, RNA activity of the Protein autophosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRSF3, MARVELD1, and HNRNPA3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SRSF3 grouped by Protein autophosphorylation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SRSF3 →	+0.658	+0.241	.001	.004	2	4
LUNG_SCLC	MARVELD1 →	-1.919	-0.170	.006	.009	3	3
LUNG_SCLC	HNRNPA3 →	+0.647	+0.129	<.001	.005	3	3
BREAST	NT5E →	-1.779	-0.128	.003	.002	3	3
BREAST	PIM1 →	-1.390	-0.157	.003	.007	3	3
BREAST	GALNT2 →	-1.146	-0.128	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SRSF3 by Protein autophosphorylation activity — LIVER

Explore this box plot interactively →