Protein autophosphorylation

Across TCGA cell cohorts, RNA activity of the Protein autophosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSNK1G2, LRSAM1, and ENC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein autophosphorylation activity versus CSNK1G2 in BLOOD_Leukemia (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CSNK1G2 →	+0.472	+0.758	.005	.004	3	4
BREAST	LRSAM1 →	+0.681	+0.730	.001	.004	2	5
PANCREAS	ENC1 →	-1.765	-0.530	.004	.005	3	4
PANCREAS	LONP1 →	+1.165	+0.394	<.001	.006	3	4
PANCREAS	S100A10 →	-1.587	-0.839	.004	.009	3	4
BLOOD_Lymphoma	BCAT2 →	+0.677	+0.970	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046777 vs CSNK1G2 — BLOOD_Leukemia

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