Viral budding

Across TCGA patient cohorts, RNA activity of the Viral budding pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL30, GDPD1, and RPL35A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Viral budding activity versus RPL30 in BRCA (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPL30 →	-0.135	-0.029	.004	.005	2	5
GBM	GDPD1 →	+0.427	+0.046	.002	.003	3	4
GBM	RPL35A →	-0.253	-0.038	.002	.001	3	4
CCRCC	SEC61B →	-0.419	-0.042	.004	<.001	3	4
CCRCC	COPZ1 →	-0.168	-0.032	.001	.001	3	4
CCRCC	RARS1 →	-0.203	-0.038	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046755 vs RPL30 — BRCA

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