Viral budding

Across TCGA cell cohorts, RNA activity of the Viral budding pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRC41, TTC9, and VPS54, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LRRC41 grouped by Viral budding-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LRRC41 →	-0.718	-0.309	.001	.009	3	4
PANCREAS	TTC9 →	+2.017	+0.173	<.001	<.001	3	4
BLOOD_Lymphoma	VPS54 →	-2.053	-0.309	.002	.009	3	4
URINARY_TRACT	FOXN2 →	-1.063	-0.235	<.001	.003	3	4
SOFT_TISSUE	MGRN1 →	-0.767	-0.271	.006	.007	3	4
SOFT_TISSUE	PIAS4 →	-0.592	-0.304	.003	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LRRC41 by Viral budding activity — BLOOD_Lymphoma

Explore this box plot interactively →