Viral budding

Across TCGA cell cohorts, RNA activity of the Viral budding pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CISH, SLC2A1, and PHB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Viral budding activity versus CISH in LARGE_INTESTINE (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CISH →	+0.613	+0.672	.006	<.001	3	4
SKIN	SLC2A1 →	-1.078	-0.627	.004	.004	3	4
SKIN	PHB →	+0.658	+0.615	<.001	.005	3	4
SKIN	METTL23 →	+0.577	+0.580	<.001	.009	3	4
OVARY	TIMM10 →	+0.759	+0.916	.005	.001	2	5
PANCREAS	TTC27 →	+0.770	+1.229	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046755 vs CISH — LARGE_INTESTINE

Explore this scatter interactively →