Non-lytic viral release

Across TCGA patient cohorts, RNA activity of the Non-lytic viral release pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL30, RPS7, and EPB41L1_S784, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Non-lytic viral release activity versus RPL30 in BRCA (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPL30 →	-0.214	-0.040	<.001	<.001	3	5
GBM	RPS7 →	-0.252	-0.039	.003	.006	3	5
CCRCC	EPB41L1_S784 →	+0.792	+0.040	<.001	.003	3	5
LUAD	RPL4 →	-0.246	-0.042	.001	<.001	3	4
GBM	RPS12 →	-0.243	-0.034	.005	.002	3	4
PDAC	RPS24 →	-0.268	-0.032	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046753 vs RPL30 — BRCA

Explore this scatter interactively →