Non-lytic viral release

Across TCGA cell cohorts, RNA activity of the Non-lytic viral release pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BECN1, CISD3, and MLX, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Non-lytic viral release activity versus BECN1 in LARGE_INTESTINE (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BECN1 →	+0.437	+0.714	.002	.006	3	5
STOMACH	CISD3 →	+1.268	+1.519	.002	<.001	3	4
LARGE_INTESTINE	MLX →	+0.660	+1.062	.001	.003	3	4
SKIN	RAD51D →	+0.505	+0.666	.004	.004	3	4
SKIN	NME1 →	+0.687	+0.899	.002	.009	3	4
STOMACH	SMPD3 →	+2.376	+1.528	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046753 vs BECN1 — LARGE_INTESTINE

Explore this scatter interactively →