Regulation by virus of viral protein levels in host cell

Across TCGA patient cohorts, RNA activity of the Regulation by virus of viral protein levels in host cell pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX58, MX2, and OAS2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation by virus of viral protein levels in host cell activity versus DDX58 in GBM (Pearson r = 0.55).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DDX58 →	+0.662	+0.080	<.001	<.001	3	9
GBM	MX2 →	+0.792	+0.085	<.001	<.001	3	9
UCEC	OAS2 →	+0.980	+0.113	<.001	<.001	3	9
GBM	XAF1 →	+0.718	+0.082	.001	.001	3	8
PDAC	EPSTI1 →	+0.613	+0.090	<.001	<.001	3	8
GBM	IFIT1 →	+1.022	+0.110	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046719 vs DDX58 — GBM

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