Regulation by virus of viral protein levels in host cell

Across TCGA patient cohorts, RNA activity of the Regulation by virus of viral protein levels in host cell pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STAT1, IFIT2, and NMI, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation by virus of viral protein levels in host cell activity versus STAT1 in UCEC (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT1 →	+1.042	+0.208	<.001	<.001	3	5
HNSC	IFIT2 →	+1.438	+0.109	<.001	.001	3	5
HNSC	NMI →	+0.845	+0.125	<.001	<.001	3	5
HNSC	NLRC5 →	+0.724	+0.106	<.001	<.001	3	5
HNSC	GBP5 →	+1.440	+0.092	<.001	.002	3	5
HNSC	SMTNL1 →	+0.860	+0.119	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046719 vs STAT1 — UCEC

Explore this scatter interactively →