Muscle cell cellular homeostasis

Across TCGA patient cohorts, RNA activity of the Muscle cell cellular homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DPEP2, SAMD10, and LILRB5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Muscle cell cellular homeostasis activity versus DPEP2 in BRCA (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DPEP2 →	+0.550	+0.294	.004	<.001	3	5
UCEC	SAMD10 →	-0.473	-0.113	<.001	.008	3	5
OV	LILRB5 →	+0.493	+0.221	<.001	.004	3	5
HNSC	PRUNE2 →	+1.790	+0.292	<.001	<.001	3	5
UCEC	CPA3 →	+0.961	+0.143	.001	<.001	3	5
UCEC	IRAG1 →	+0.800	+0.202	.005	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046716 vs DPEP2 — BRCA

Explore this scatter interactively →