Muscle cell cellular homeostasis

Across TCGA cell cohorts, RNA activity of the Muscle cell cellular homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PFKM, EARS2, and TJP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Muscle cell cellular homeostasis activity versus PFKM in BONE (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PFKM →	+1.885	+0.300	.002	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	EARS2 →	+0.984	+0.222	.001	.003	3	6
LUNG_SCLC	TJP2 →	-2.220	-0.177	.003	.001	3	5
BLOOD_Myeloma	MRPS34 →	+0.805	+0.249	.002	.006	2	6
BLOOD_Lymphoma	IMP4 →	+0.989	+0.146	.003	.007	3	5
UPPER_AERODIGESTIVE_TRACT	SHTN1 →	+1.092	+0.240	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046716 vs PFKM — BONE

Explore this scatter interactively →