GDP metabolic process

Across TCGA patient cohorts, RNA activity of the GDP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL19P4, GRIN2D, and BTF3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, GDP metabolic process activity versus RPL19P4 in COAD (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPL19P4 →	-0.326	-0.423	<.001	.004	3	3
CCRCC	GRIN2D →	+0.198	+0.366	<.001	<.001	3	3
LSCC	BTF3 →	-0.265	-0.205	.009	.005	3	3
GBM	LINC02785 →	-0.420	-0.366	<.001	.004	3	3
HNSC	PYGM →	-0.851	-0.261	.009	.005	3	3
CCRCC	NACA →	-0.280	-0.269	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046710 vs RPL19P4 — COAD

Explore this scatter interactively →