GDP metabolic process

Across TCGA cell cohorts, RNA activity of the GDP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHLDA3, UBTD1, and SFXN1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PHLDA3 grouped by GDP metabolic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PHLDA3 →	-2.173	-1.333	.005	<.001	2	8
LUNG_NSCLC_LUAD	UBTD1 →	-0.927	-0.589	.001	.006	3	5
SKIN	SFXN1 →	+0.906	+0.930	.006	<.001	3	4
SKIN	RRM2B →	-0.835	-1.007	.004	.001	3	4
PANCREAS	IL1R2 →	-1.716	-1.396	.008	<.001	3	3
KIDNEY	KLC4 →	+0.891	+1.367	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PHLDA3 by GDP metabolic process activity — SKIN

Explore this box plot interactively →